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pentobarbital decreases amounts of toremifene by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers enhance rate of toremifene metabolism, decreasing the continual-point out concentration in serum.pentobarbital will lower the level or result of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism